4 min 4 steps
Objective
Calculate the PSA doubling time and velocity to support decisions in active surveillance and follow-up.
Clinical scenario
In active surveillance and after surgery, PSA kinetics is the earliest sign of progression. The app computes PSADT and velocity from a series of values.
Step by step in the app
- 1
Enter the PSA series
In the MSKCC PSADT module, provide the PSA values with their dates.
- 2
Read the doubling time
The app runs a linear regression on log(PSA) and returns the PSADT in months.
- 3
See the velocity
PSA velocity (ng/mL/year) complements the kinetics reading.
- 4
Cross-check with PSA density
Use the density module to weight the absolute value by prostate volume.
Clinical pearls
- A short PSADT is a warning sign even with a low absolute PSA — kinetics rules.
- You need at least 3 time points for a stable doubling-time estimate.
References
- MSKCC nomograms — PSADT and PSA density